Phenotypes Associated with This Genotype

Genotype
MGI:3582961

• Allelic Composition: Npc1l1^tm1Yaio/Npc1l1^tm1Yaio
• Genetic Background: C57BL/6-Npc1l1^tm1Yaio

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:98568 )

decreased circulating glucose level ( J:98568 )

• plasma glucose levels decreased when fed a high fat diet

abnormal lipid homeostasis ( J:98568 )

abnormal intestinal lipid absorption ( J:98568 )

• reduced sphingolipid uptake

decreased intestinal cholesterol absorption ( J:98568 )

• radiolabeled cholesterol influx rates were reduced by 30%

abnormal cholesterol homeostasis ( J:98568 )

abnormal circulating LDL cholesterol level ( J:98568 )

• resistance to diet-induced LDL cholesterol elevation

decreased circulating cholesterol level ( J:98568 )

• total cholesterol levels decreased when fed a high fat diet

decreased circulating HDL cholesterol level ( J:98568 )

• when fed a high fat diet HDL levels decreased

abnormal triglyceride level ( J:98568 )

• resistant to diet induced increases in triglyceride levels

decreased susceptibility to hyperlipidemia ( J:98568 )

• plasma lipid levels, liver and gall bladder morphology and liver histology demonstrated resistance to diet-induced hypercholesterolemia

digestive/alimentary system

abnormal intestinal lipid absorption ( J:98568 )

• reduced sphingolipid uptake

decreased intestinal cholesterol absorption ( J:98568 )

• radiolabeled cholesterol influx rates were reduced by 30%

liver/biliary system

decreased susceptibility to diet-induced hepatic steatosis ( J:98568 )

• liver sections and histochemical analysis demonstrated a resistance to diet induced fatty liver

abnormal gallbladder physiology ( J:98568 )

• resistance to lipid-induced cholestasis of the gall bladder when fed a high fat diet

growth/size/body

decreased susceptibility to diet-induced obesity ( J:98568 )