Phenotypes Associated with This Genotype

Genotype
MGI:3582958

• Allelic Composition: Slc6a4^tm1Kpl/Slc6a4^tm1Kpl
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal body temperature homeostasis ( J:59654 )

• no hypothermia in response to 8-hydroxy-2-(di-n-propylamino)tetraline treatment is seen unlike in wild-type mice

decreased serotonin level ( J:76020 )

• a 60-80% decrease in serotonin levels in the brain stem, frontal cortex, hippocampus, and striatum is seen

behavior/neurological

decreased locomotor activity ( J:76020 )

• (+)3,4-methylenedioxymethamphetamine (MDMA) does not induce hyperactivity but instead results in hypoactivity 10 and 30 minutes after treatment