Mouse Genome Informatics
ht
    Bicc1jcpk/Bicc1jcpk-bpk
involves: 101 * BALB/c * C3H * C57BL/6J * T STOCK
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
renal/urinary system
• small opalescent cysts seen at 11 to 17 days of age
• cysts are radially arrayed, a pattern typical of cysts in the collecting ducts and cystic dilation of Bowman's space involving about 17% of glomeruli, similar to Bicc1jcpk-bpk homozygotes

liver/biliary system
• tortuous ducts are generally lined with hyperplastic epithelium
• gall bladder dilation is common
• expanded portal tracts with multiple irregularly shaped and variably dilated bile ducts
• the portal triad is expanded by hematopoietic cells and immature stromal cells
• liver parenchyma is pale

growth/size/body
• visible by 7 to 10 days of age

endocrine/exocrine glands
• tortuous ducts are generally lined with hyperplastic epithelium
• gall bladder dilation is common

Mouse Models of Human Disease
OMIM IDRef(s)
Polycystic Kidney Disease, Autosomal Recessive; ARPKD 263200 J:36348