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Phenotypes Associated with This Genotype
Genotype
MGI:3582934
Allelic
Composition
Bicc1jcpk/Bicc1jcpk-bpk
Genetic
Background
involves: 101 * BALB/c * C3H * C57BL/6J * T STOCK
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bicc1jcpk mutation (0 available); any Bicc1 mutation (21 available)
Bicc1jcpk-bpk mutation (0 available); any Bicc1 mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• small opalescent cysts seen at 11 to 17 days of age
• cysts are radially arrayed, a pattern typical of cysts in the collecting ducts and cystic dilation of Bowman's space involving about 17% of glomeruli, similar to Bicc1jcpk-bpk homozygotes

liver/biliary system
• tortuous ducts are generally lined with hyperplastic epithelium
• gall bladder dilation is common
• expanded portal tracts with multiple irregularly shaped and variably dilated bile ducts
• the portal triad is expanded by hematopoietic cells and immature stromal cells
• liver parenchyma is pale

growth/size/body
• visible by 7 to 10 days of age

endocrine/exocrine glands
• tortuous ducts are generally lined with hyperplastic epithelium
• gall bladder dilation is common

Mouse Models of Human Disease
OMIM ID Ref(s)
Polycystic Kidney Disease, Autosomal Recessive; ARPKD 263200 J:36348


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory