Phenotypes Associated with This Genotype

Genotype
MGI:3582929

• Allelic Composition: Bicc1^jcpk-bpk/Bicc1^jcpk-bpk
• Genetic Background: involves: BALB/c * CAST/EiJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:36348 )

• die between 14 and 21 days of age

• Background Sensitivity: lethality occurs earlier compared to homozygotes on an inbred BALB/c background which die at 4 to 5 weeks of age

renal/urinary system

kidney cyst ( J:36348 )

• Background Sensitivity: kidney cysts at 14 days of age are similar those in homozygotes on an inbred BALB/c background at 24 to 28 days of age

enlarged kidney ( J:36348 )

liver/biliary system

dilated gallbladder ( J:36348 )

• gall bladder dilation is common

pale liver ( J:36348 )

• liver parenchyma is pale

growth/size/body

kidney cyst ( J:36348 )

• Background Sensitivity: kidney cysts at 14 days of age are similar those in homozygotes on an inbred BALB/c background at 24 to 28 days of age

decreased body size ( J:36348 )

• significantly runted shortly after birth

distended abdomen ( J:36348 )

• detected at 9 to 15 days of age

• Background Sensitivity: distension was not seen on an inbred BALB/c background until after 2 weeks of age

enlarged kidney ( J:36348 )

endocrine/exocrine glands

dilated gallbladder ( J:36348 )

• gall bladder dilation is common

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autosomal recessive polycystic kidney disease		DOID:0110861	OMIM:263200	J:36348