Phenotypes Associated with This Genotype

Genotype
MGI:3582836

• Allelic Composition: Cdk4^tm1.1Bbd/Cdk4⁺; Kras^tm1Bbd/Kras⁺; Tg(CMV-cre)1Cgn/?
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased pituitary adenoma incidence ( J:86101 )

increased lung adenoma incidence ( J:86101 )

• latency to develop lung adenomas is significantly shorter compared to double mutants wild-type for Cdk4; however development of tumors characteristic of Cdk4^tm1.1Bbd mutant mice is not accelerated

increased sarcoma incidence ( J:86101 )

• histiocytic sarcoma and other sarcomas are seen

increased hemangiosarcoma incidence ( J:86101 )

increased papilloma incidence ( J:86101 )

• anal papillomas are seen

digestive/alimentary system

abnormal pancreatic duct morphology ( J:86101 )

• focal metaplasia in the pancreatic ducts consisting of tall columnar cells with abundant apical mucin resembling gastric surface epithelial cells

endocrine/exocrine glands

abnormal pancreatic duct morphology ( J:86101 )

• focal metaplasia in the pancreatic ducts consisting of tall columnar cells with abundant apical mucin resembling gastric surface epithelial cells

increased pituitary adenoma incidence ( J:86101 )

nervous system

increased pituitary adenoma incidence ( J:86101 )

respiratory system

increased lung adenoma incidence ( J:86101 )

• latency to develop lung adenomas is significantly shorter compared to double mutants wild-type for Cdk4; however development of tumors characteristic of Cdk4^tm1.1Bbd mutant mice is not accelerated