Phenotypes Associated with This Genotype

Genotype
MGI:3582835

• Allelic Composition: Kras^tm1Bbd/Kras⁺; Tg(CMV-cre)1Cgn/?
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:86101 )

• double mutants develop breathing difficulties after 7 - 8 months of age

prenatal lethality, incomplete penetrance ( J:86101 )

• frequent embryonic lethality; however, a significant number of double mutants survive

neoplasm

increased lung adenoma incidence ( J:86101 )

• a large spectrum of multifocal lesions are seen in the lung including; small patches of bronchiolo-alveolar hyperplasias to large bronchiolo-alveolar adenomas that compress adjacent lung structures and appear to derive from type II pneumocytes

increased lung adenocarcinoma incidence ( J:86101 )

• large bronchiolo-alveolar adenocarcinomas that compress adjacent lung structures and appear to derive from type II pneumocytes

increased sarcoma incidence ( J:86101 )

• histiocytic sarcoma and other sarcomas seen in 2 out of 20 and 3 out of 20 double mutants, respectively

increased papilloma incidence ( J:86101 )

• anal papillomas seen in 3 out of 20 double mutants

cellular

abnormal cell proliferation ( J:86101 )

• MEFs expressing the oncogenic protein do not undergo proliferative senescence and proliferate continuously as immortal cells

respiratory system

increased lung adenoma incidence ( J:86101 )

• a large spectrum of multifocal lesions are seen in the lung including; small patches of bronchiolo-alveolar hyperplasias to large bronchiolo-alveolar adenomas that compress adjacent lung structures and appear to derive from type II pneumocytes

increased lung adenocarcinoma incidence ( J:86101 )

• large bronchiolo-alveolar adenocarcinomas that compress adjacent lung structures and appear to derive from type II pneumocytes

respiratory distress ( J:86101 )

• double mutants develop breathing difficulties after 7 - 8 months of age