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Phenotypes Associated with This Genotype
Genotype
MGI:3582680
Allelic
Composition
Mafatm1Staka/Mafatm1Staka
Genetic
Background
involves: ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mafatm1Staka mutation (1 available); any Mafa mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• females displayed significant growth retardation postnatally from 8 weeks onward

homeostasis/metabolism
• almost no acute insulin secretion in response to elevated blood glucose levels and pancreatic islets did not secrete insulin in response to glucose, arginine, or KCl stimulation in vitro
• significantly higher fasting blood glucose levels in females at 4 weeks of age, and both males and females had high blood glucose levels at 8 weeks of age
• significantly lower plasma insulin levels after glucose injection (0.51 ng/ml vs 1.51 ng/ml in wild-type) or arginine administration
• significantly higher blood glucose levels than wild-type in a glucose tolerance test
• 5/19 adult males became urinary glucose positive by 20 weeks of age

endocrine/exocrine glands
• significant difference in the structure of islets and the ratio of beta to alpha cells at 12 weeks of age but not at P1
• almost no acute insulin secretion in response to elevated blood glucose levels and pancreatic islets did not secrete insulin in response to glucose, arginine, or KCl stimulation in vitro

renal/urinary system
• 5/19 adult males became urinary glucose positive by 20 weeks of age


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory