Phenotypes Associated with This Genotype

Genotype
MGI:3582650

• Allelic Composition: Rbl1^tm1Tyj/Rbl1^tm1Tyj; Rbl2^tm1Tyj/Rbl2⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:34725 )

• mutants die at an increased rate during the first and second week after birth; survivors fail to reach normal adult weight

limbs/digits/tail

abnormal forelimb morphology ( J:34725 )

• at 18.0 dpc, mutant mice exhibit forelimb shortening and thickening

short limbs ( J:34725 )

• beginning at 15.0-16.0 dpc, mutants display a mild reduction in limb length

short forelimb ( J:34725 )

• at 18.0 dpc

reproductive system

delayed fertility ( J:34725 )

• surviving mutant mice display delayed fertility

reduced female fertility ( J:34725 )

♀ • surviving mutant females show reduced fertility

craniofacial

short snout ( J:34725 )

• beginning at 15.0-16.0 dpc, mutants display a mildly shortened snout

growth/size/body

short snout ( J:34725 )

• beginning at 15.0-16.0 dpc, mutants display a mildly shortened snout

decreased body weight ( J:34725 )

• mutant mice display normal weight at birth but reach only ~65% of normal weight at the age of 2-3 weeks

distended abdomen ( J:34725 )

• beginning at 15.0-16.0 dpc, mutants display a slightly distended abdomen