Phenotypes Associated with This Genotype

Genotype
MGI:3582635

• Allelic Composition: Sox2^tm1Rlb/Sox2^tm1Rlb
• Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * MF1)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:81180 )

• die shortly after implantation

embryo

abnormal ectoderm development ( J:81180 )

• epithelial cells of the epiblast were absent

• Oct4 expression was absent in mutant embryonic epiblast

• H19 expression was similar to controls indicating that the specification of extraembryonic lineages was not affected

• a normal ICM is developed, but the cells of the epiblast are not maintained

• cultured embryos also do not express markers of the epiblast and these cells appear to develop into trophoblast cells instead of epiblast

absent egg cylinders ( J:81180 )

• no egg cylinder structure was present including the extraembryonic portion

absent ectoplacental cone ( J:81180 )

• no recognizable structure was present