Analysis Tools
normal phenotype
|
• homozygotes are viable and fertile, and display no detectable histologic abnormalities at birth or at 2 months of age
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cellular
| N |
• surprisingly, mouse embryonic fibroblasts derived from homozygous mutants exhibit normal growth characteristics in culture
• gel mobility shft analysis indicated that Rbl1 largely replaces Rbl2 as the major E2F-associated species in mutant fibroblasts
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integument
| N |
• newborn homozygotes display normal epidermal terminal differentiation relative to heterozygous mutant littermates
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