Phenotypes Associated with This Genotype

Genotype
MGI:3582589

• Allelic Composition: Klf7^tm1Rmz/Klf7^tm1Rmz
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:99181 )

• 98.5% died within the first 3 days of life

homeostasis/metabolism

cyanosis ( J:99181 )

respiratory system

hypopnea ( J:99181 )

behavior/neurological

absent gastric milk in neonates ( J:99181 )

• little or no milk in neonatal stomachs

unresponsive to tactile stimuli ( J:99181 )

• failed response to clamp stimulation of tails

nervous system

abnormal axon extension ( J:99181 )

• reduced axon growth of olfactory sensory neurons

• cortical efferent projections fail to enter the internal capsule

abnormal axon guidance ( J:99181 )

• retinal ganglion cell axons project to the optic nerve head properly, but a small portion make aberrant projections and fail to exit the retina

abnormal brain morphology ( J:99181 )

abnormal telencephalon morphology ( J:99181 )

abnormal corpus callosum morphology ( J:99181 )

• fibers of the corpus callosum do not cross the midline

abnormal dentate gyrus morphology ( J:99181 )

• abnormal arbors of granule cells of the dentate gyrus

abnormal hippocampal fimbria morphology ( J:99181 )

• fimbria is reduced in size

abnormal hippocampus pyramidal cell morphology ( J:99181 )

• reduced complexity of both apical and basal dendritic trees of CA1 pyramidal cells

abnormal cerebral cortex morphology ( J:99181 )

• 30% thinner and about 15% fewer cells than in wild-type

• cortical afferent fibers are hyperfasciculated

• abnormal arbors of cortical neurons

small olfactory bulb ( J:99181 )

• severely hypoplastic olfactory bulbs

abnormal sensory neuron innervation pattern ( J:99181 )

• retinal ganglion cell axons project to the optic nerve head properly, but a small portion make aberrant projections and fail to exit the retina

• retinal ganglion cells showed projection errors at the chiasm, with an increase in ipsilaterally projecting fibers

abnormal olfactory neuron innervation pattern ( J:99181 )

• olfactory sensory neurons do not innervate the olfactory bulb

• olfactory sensory neuron axon projections towards the forebrain are poor and olfactory sensory neurons form fewer neurites at E11.5

abnormal nervous system tract morphology ( J:99181 )

• medial tracts are misrouted just before entering the cortical fiber layer

• abnormal arbors of the major fiber tracts

absent anterior commissure ( J:99181 )

• anterior commissure is missing or severely disrupted

abnormal olfactory nerve morphology ( J:99181 )

• although the overall architecture of the olfactory cavity is normal, the olfactory nerve ends in a tangle of axons

• olfactory nerve fails to contact the E12.5 forebrain and later at E17.5 remains on the inner surface of the cribriform plate

cellular

abnormal axon extension ( J:99181 )

• reduced axon growth of olfactory sensory neurons

• cortical efferent projections fail to enter the internal capsule

abnormal axon guidance ( J:99181 )

• retinal ganglion cell axons project to the optic nerve head properly, but a small portion make aberrant projections and fail to exit the retina