Phenotypes Associated with This Genotype

Genotype
MGI:3582557

• Allelic Composition: Sox2^lcc/Sox2^lcc
• Genetic Background: involves: 101/H * C3H/HeH

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

head bobbing ( J:77358 )

• described as vigorous

circling ( J:77358 )

abnormal sensory capabilities/reflexes/nociception ( J:77358 )

• no behavioral responses to sound

hearing/vestibular/ear

abnormal inner ear morphology ( J:98458 )

absent cochlear hair cells ( J:98458 )

• no evidence of formation of inner ear hair cells at P0

decreased cochlea coiling ( J:98458 )

• undercoiled cochlea

abnormal semicircular canal morphology ( J:98458 )

• rudimentary development

small utricle ( J:98458 )

small vestibular saccule ( J:98458 )

abnormal sulcus ampullaris morphology ( J:98458 )

• absent ampullae and sensory cristae

absent cochlear nerve compound action potential ( J:77358 )

• no cochlear nerve response at any frequency

pigmentation

yellow coat color ( J:77358 )

nervous system

absent cochlear hair cells ( J:98458 )

• no evidence of formation of inner ear hair cells at P0

absent cochlear nerve compound action potential ( J:77358 )

• no cochlear nerve response at any frequency

integument

abnormal awl hair morphology ( J:77358 )

• reduced number of total awl hairs, and reduced frequency of black awls

yellow coat color ( J:77358 )

abnormal guard hair morphology ( J:77358 )

• monotrich hairs showed long subapical pheomelanin bands

abnormal zigzag hair morphology ( J:77358 )