mortality/aging
• all heterozygous mutant mice die between 8.5 and 13.9 months of age
|
neoplasm
N |
• in addition, no precursor lesions (retinomas) are detected by indirect ophthalmology or histological evaluation
• up to 11 months of age, none of >100 heterozygotes studied show any macroscopic sign of retinoblastoma relative to wild-type mice
|
• at autopsy, heterozygotes with severe wasting symptoms show large pituitary adenocarcinomas (~ 6 mm in diameter)
(J:2511)
• consistent with the "two-hit" model proposed by Knudson, such pituitary tumors are shown to arise from cells in which the wild-type allele is absent
(J:2511)
• heterozygotes develop intermediate lobe pituitary tumors
(J:81082)
|
• 23/27 heterozygotes show c-cell thyroid tumors
|
growth/size/body
endocrine/exocrine glands
• at autopsy, heterozygotes with severe wasting symptoms show large pituitary adenocarcinomas (~ 6 mm in diameter)
(J:2511)
• consistent with the "two-hit" model proposed by Knudson, such pituitary tumors are shown to arise from cells in which the wild-type allele is absent
(J:2511)
• heterozygotes develop intermediate lobe pituitary tumors
(J:81082)
|
• 23/27 heterozygotes show c-cell thyroid tumors
|
nervous system
• at autopsy, heterozygotes with severe wasting symptoms show large pituitary adenocarcinomas (~ 6 mm in diameter)
(J:2511)
• consistent with the "two-hit" model proposed by Knudson, such pituitary tumors are shown to arise from cells in which the wild-type allele is absent
(J:2511)
• heterozygotes develop intermediate lobe pituitary tumors
(J:81082)
|