Phenotypes Associated with This Genotype

Genotype
MGI:3582523

• Allelic Composition: E2f4^tm1Lees/E2f4⁺; Rb1^tm1Tyj/Rb1⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:81082 )

• died by 18 months of age compared to 20-27 months in wild-type

neoplasm

increased pituitary gland tumor incidence ( J:81082 )

• developed pituitary tumors that were comparable to those arising in single heterozygous mutant Rb1 mice with respect to both incidence and size

increased thyroid tumor incidence ( J:81082 )

• developed thyroid tumors that were comparable to those arising in single heterozygous mutant Rb1 mice with respect to both incidence and size

endocrine/exocrine glands

increased pituitary gland tumor incidence ( J:81082 )

• developed pituitary tumors that were comparable to those arising in single heterozygous mutant Rb1 mice with respect to both incidence and size

increased thyroid tumor incidence ( J:81082 )

• developed thyroid tumors that were comparable to those arising in single heterozygous mutant Rb1 mice with respect to both incidence and size

nervous system

increased pituitary gland tumor incidence ( J:81082 )

• developed pituitary tumors that were comparable to those arising in single heterozygous mutant Rb1 mice with respect to both incidence and size