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Phenotypes Associated with This Genotype
Genotype
MGI:3582401
Allelic
Composition		 Cd180tm1Kmiy/Cd180tm1Kmiy
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd180tm1Kmiy mutation (5 available); any Cd180 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal humoral immune response ( J:63145 )
• impaired proliferative and humoral immune responses of B cells to lipopolysaccharides
decreased IgG2b level ( J:137066 )
• reduced in serum at 7 and 11 weeks of age
decreased IgG3 level ( J:137066 )
• significantly reduced in serum at 7 and 11 weeks of age

hematopoietic system
decreased IgG2b level ( J:137066 )
• reduced in serum at 7 and 11 weeks of age
decreased IgG3 level ( J:137066 )
• significantly reduced in serum at 7 and 11 weeks of age

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory