Analysis Tools
immune system
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• homozygous mice that are also hemizygous or homozygous mice for Tg(Lck-cre)548Jxm, in which cre recombinase is active in T cell lineage, display: total thymic cellularity was reduced by 40-50%
• the number of mature CD4 positive and CD8 positive T lymphocytes in the spleen was reduced by 40-50%
• however, mutant has a normal CD4- positive and CD8-positive effector and memory T cell development
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• after 1-2 days of culture, the number of cells in the double-positive compartment were dramatically reduced
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hematopoietic system
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• homozygous mice that are also hemizygous or homozygous mice for Tg(Lck-cre)548Jxm, in which cre recombinase is active in T cell lineage, display: total thymic cellularity was reduced by 40-50%
• the number of mature CD4 positive and CD8 positive T lymphocytes in the spleen was reduced by 40-50%
• however, mutant has a normal CD4- positive and CD8-positive effector and memory T cell development
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• after 1-2 days of culture, the number of cells in the double-positive compartment were dramatically reduced
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endocrine/exocrine glands
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• homozygous mice that are also hemizygous or homozygous mice for Tg(Lck-cre)548Jxm, in which cre recombinase is active in T cell lineage, display: total thymic cellularity was reduced by 40-50%
• the number of mature CD4 positive and CD8 positive T lymphocytes in the spleen was reduced by 40-50%
• however, mutant has a normal CD4- positive and CD8-positive effector and memory T cell development
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