Mouse Genome Informatics
hm
    Chrm3tm1Mmt/Chrm3tm1Mmt
involves: 129X1/SvJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       

Pupil appearance of Chrm3tm1Mmt/+ and Chrm3tm1Mmt/Chrm3tm1Mmt mice.

growth/size
• smaller at around 3 weeks of age
• average body weight is only half that of controls at 4-5 weeks of age, however by 15 weeks of age, homozygous males catch up with controls while homozygous females remain smaller and are about 80% of wild-type weight

vision/eye
• exhibit dilated ocular pupils, however find no other eye abnormalities
• no change in pupil size in response to pilocarpine, a nonselective muscarinic agonist, however atropine instillation causes further dilation and completed mydriasis

renal/urinary system
• contractility of the detrusor muscles by carbachol, but not KCl, stimulation is decreased to only 5% of that seen in wild-type
• mild hydronephrosis in 3 of 10 homozygous males, showing a distended renal calyx with some perivascular lymphocyte infiltrations in the adjacent medulla
• bladder wall is thinner because of the severe distension and the submucosal layer contains some focal lymphocyte infiltrations in homozygous males, while the urothelium and renal function appear normal
• severely distended in males and mildly distended in females

muscle
• maximal contraction of ileal smooth muscle in response to carbachol, but not KCl, is decreased by 77% in males and by 72% in females
• contractility of the detrusor muscles by carbachol, but not KCl, stimulation is decreased to only 5% of that seen in wild-type

digestive/alimentary system
• salivary secretion is abolished in response to pilocarpine but not to isoproterenol, a beta-adrenergic agonist

endocrine/exocrine glands
• salivary secretion is abolished in response to pilocarpine but not to isoproterenol, a beta-adrenergic agonist

homeostasis/metabolism
• salivary secretion is abolished in response to pilocarpine but not to isoproterenol, a beta-adrenergic agonist

Mouse Models of Human Disease
OMIM IDRef(s)
Visceral Myopathy; VSCM 155310 J:64069