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Phenotypes Associated with This Genotype
Genotype
MGI:3581978
Allelic
Composition
Chrm3tm1Mmt/Chrm3tm1Mmt
Genetic
Background
involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chrm3tm1Mmt mutation (0 available); any Chrm3 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Pupil appearance of Chrm3tm1Mmt/+ and Chrm3tm1Mmt/Chrm3tm1Mmt mice.

growth/size/body
• smaller at around 3 weeks of age (J:64069)
• smaller at around 3 weeks of age (J:64069)
• average body weight is only half that of controls at 4-5 weeks of age, however by 15 weeks of age, homozygous males catch up with controls while homozygous females remain smaller and are about 80% of wild-type weight (J:64069)
• average body weight is only half that of controls at 4-5 weeks of age, however by 15 weeks of age, homozygous males catch up with controls while homozygous females remain smaller and are about 80% of wild-type weight (J:64069)

vision/eye
• exhibit dilated ocular pupils, however find no other eye abnormalities (J:64069)
• no change in pupil size in response to pilocarpine, a nonselective muscarinic agonist, however atropine instillation causes further dilation and completed mydriasis (J:64069)
• exhibit dilated ocular pupils, however find no other eye abnormalities (J:64069)
• no change in pupil size in response to pilocarpine, a nonselective muscarinic agonist, however atropine instillation causes further dilation and completed mydriasis (J:64069)

renal/urinary system
• contractility of the detrusor muscles by carbachol, but not KCl, stimulation is decreased to only 5% of that seen in wild-type (J:64069)
• contractility of the detrusor muscles by carbachol, but not KCl, stimulation is decreased to only 5% of that seen in wild-type (J:64069)
• mild hydronephrosis in 3 of 10 homozygous males, showing a distended renal calyx with some perivascular lymphocyte infiltrations in the adjacent medulla (J:64069)
• mild hydronephrosis in 3 of 10 homozygous males, showing a distended renal calyx with some perivascular lymphocyte infiltrations in the adjacent medulla (J:64069)
• bladder wall is thinner because of the severe distension and the submucosal layer contains some focal lymphocyte infiltrations in homozygous males, while the urothelium and renal function appear normal (J:64069)
• bladder wall is thinner because of the severe distension and the submucosal layer contains some focal lymphocyte infiltrations in homozygous males, while the urothelium and renal function appear normal (J:64069)
• severely distended in males and mildly distended in females (J:64069)
• severely distended in males and mildly distended in females (J:64069)

muscle
• maximal contraction of ileal smooth muscle in response to carbachol, but not KCl, is decreased by 77% in males and by 72% in females (J:64069)
• maximal contraction of ileal smooth muscle in response to carbachol, but not KCl, is decreased by 77% in males and by 72% in females (J:64069)
• contractility of the detrusor muscles by carbachol, but not KCl, stimulation is decreased to only 5% of that seen in wild-type (J:64069)
• contractility of the detrusor muscles by carbachol, but not KCl, stimulation is decreased to only 5% of that seen in wild-type (J:64069)

digestive/alimentary system
• salivary secretion is abolished in response to pilocarpine but not to isoproterenol, a beta-adrenergic agonist (J:64069)
• salivary secretion is abolished in response to pilocarpine but not to isoproterenol, a beta-adrenergic agonist (J:64069)

endocrine/exocrine glands
• salivary secretion is abolished in response to pilocarpine but not to isoproterenol, a beta-adrenergic agonist (J:64069)
• salivary secretion is abolished in response to pilocarpine but not to isoproterenol, a beta-adrenergic agonist (J:64069)

homeostasis/metabolism
• salivary secretion is abolished in response to pilocarpine but not to isoproterenol, a beta-adrenergic agonist (J:64069)
• salivary secretion is abolished in response to pilocarpine but not to isoproterenol, a beta-adrenergic agonist (J:64069)

Mouse Models of Human Disease
OMIM ID Ref(s)
Visceral Myopathy; VSCM 155310 J:64069


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory