Analysis Tools
immune system
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• in vitro, double-mutant erythrocytes display a significantly increased sensitivity to antibody-induced autologous and heterologous complement lysis by membrane attack complex (MAC) relative to wild-type or single mutant erythrocytes
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hematopoietic system
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• despite enhanced sensitivity to antibody-induced complement lysis in vitro, double mutants develop no signs of hemolytic anemia and are resistant to spontaneous complement attack in vivo
• total peripheral erythrocyte counts, blood hemoglobin concentrations, and the average reticulocyte count remain unaffected; transfusion experiments confirm normal erythrocyte lifespans in vivo
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