Mouse Genome Informatics
involves: 129S2/SvPas * C57BL/6
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• less than 1% of neurons in cerebral cortex were ballooned at 60 days of age
• contained secondary lysosomes containing poorly defined lamellar structures and lipofuscin like material
• 10% of neurons in neocortex were ballooned by 150 days of age and contained dense vacuoles in cytoplasm

liver/biliary system
• at 150 days of age, generally normal liver contained rare clusters of hepatocytes with abnormal expansions of the lysosomal apparatus

Mouse Models of Human Disease
Tay-Sachs Disease; TSD 272800 J:30435