Phenotypes Associated with This Genotype

Genotype
MGI:3581524

• Allelic Composition: Grin1^tm2Stl/Grin1^tm2Stl; Tg(Camk2a-cre)T29-1Stl/0
• Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal contextual conditioning behavior ( J:60730 )

• impaired hippocampus-dependent, but not hippocampus-independent, fear memory that can be rescued with enriched training

abnormal olfactory discrimination memory ( J:60730 )

• impaired olfactory-discrimination memory that can be rescued with enriched training

impaired social transmission of food preference ( J:60730 )

abnormal object recognition memory ( J:60730 )

• deficit in novel object recognition memory that can be partially rescued with enriched training

abnormal spatial learning ( J:37457 )

• impaired spatial memory in the hidden-platform Morris water maze test, with some progressive improvement in escape latencies but unimpaired nonspatial learning

nervous system

abnormal excitatory postsynaptic currents ( J:37457 )

• lack the slow component of the excitatory postsynaptic current mediated by NMDA receptors

absence of NMDA-mediated synaptic currents ( J:37457 )

• lack the slow component of the excitatory postsynaptic current mediated by NMDA receptors, however postsynaptic AMPA receptors as well as presynaptic terminals operate normally

reduced long-term potentiation ( J:37457 )

• lack long term potentiation in the CA1 synapses