Phenotypes Associated with This Genotype

Genotype
MGI:3581168

• Allelic Composition: Vac14^ingls/Vac14^ingls
• Genetic Background: B6.D2-Vac14^ingls/GrsrJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:81516 , J:142703 )

• die by 22 days of age (J:81516)

• mice die between P1 and P21 (J:142703)

nervous system

hydrocephaly ( J:81516 , J:142703 )

• often by 1 week of age and usually severe with lateral ventricles most severely affected, the third ventricle less severely affected, and the fourth ventricle normal (J:81516)

• severe at P16 (J:142703)

enlarged brain ventricles ( J:142703 )

• enlarged

gliosis ( J:81516 )

• astrocytic hypertrophy and hyperplasia in brain stem and spinal cord and to a much lesser extent in the cerebral cortex, thalamus, and midbrain, within the first weeks of life with most homozygotes developing hydrocephalus and a few developing status spongiosis

astrocytosis ( J:81516 , J:142703 )

• astrocytes from affected mice cease dividing shortly after being put in culture (J:81516)

spongiform encephalopathy ( J:81516 , J:142703 )

• in several regions of the brain including thalamus, brain stem and cerebellar nucleus (J:142703)

• however, spinal motor neurons and sensory neurons remain intact (J:142703)

behavior/neurological

tremors ( J:142703 )

• at P14

abnormal motor coordination/balance ( J:142703 )

• at P14, mice exhibit impaired motor function

ataxia ( J:81516 )

growth/size/body

decreased body size ( J:81516 , J:142703 )

pigmentation

diluted coat color ( J:142703 )

integument

diluted coat color ( J:142703 )