Phenotypes Associated with This Genotype

Genotype
MGI:3581157

• Allelic Composition: Grid2^Lc/Grid2⁺
• Genetic Background: B6CBACa A^w-J/A-Grid2^Lc/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal grooming behavior ( J:50315 )

• the number and duration of several grooming components (licking the forelimb, the abdomen, the back, and the hindlimb) is decreased compared to in wild-type mice

• however, the number and duration of body-shaking episodes is normal as is the serial organization of grooming

ataxia ( J:39109 )

• due to progressive loss of Purkinje cells

hearing/vestibular/ear

reduced linear vestibular evoked potential ( J:116914 )

• elevated threshold and reduced amplitudes

nervous system

Purkinje cell degeneration ( J:39109 )

• occurs within the first three weeks of life