Phenotypes Associated with This Genotype

Genotype
MGI:3581136

• Allelic Composition: Frs2^tm3Scl/Frs2^tm3Scl
• Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Swiss Webster)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:98883 , J:98901 )

• died over a range of stages (between E5.75 and E8), with approximately half dying shortly after implantation, and the remaining half surviving through E7.5 with growth and primitive streak defects (J:98883)

• die between E7 and E7.5 as a result of severe impairment in embryonic development (J:98901)

embryo

abnormal rostral-caudal axis patterning ( J:98883 )

• impaired anterior-posterior axis formation

embryonic growth retardation ( J:98883 )

• severely growth retarded at E7.5-E8

decreased embryo size ( J:98883 )

• 30% smaller than wild-type at E7

abnormal trophoblast giant cell morphology ( J:98883 )

• trophoblast stem cells failed to develop and proliferate in response to FGF4 when grown in culture

abnormal primitive streak elongation ( J:98883 )

• fail to assemble a properly elongating primitive streak in the posterior region

abnormal visceral endoderm morphology ( J:98883 )

• thickened visceral endoderm at the distal region of the egg cylinder at E7

growth/size/body

embryonic growth retardation ( J:98883 )

• severely growth retarded at E7.5-E8

decreased embryo size ( J:98883 )

• 30% smaller than wild-type at E7