Phenotypes Associated with This Genotype

Genotype
MGI:3581129

• Allelic Composition: Rgs4^tm1.1Jbr/Rgs4^tm1.1Jbr
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between somite formation and embryo turning, incomplete penetrance ( J:98888 )

• fewer than expected homozygous embryos are recovered at E8.5 (17% compared to 25% expected)

• Background Sensitivity: after 3 backcrosses to C57BL/6 the expected number of homozygotes was seen

behavior/neurological

impaired behavioral response to morphine ( J:98888 )

• during withdrawal from morphine the sniffing reflex is almost completely absent; however, the antinociceptive effect of morphine is similar to wild-type

decreased behavioral withdrawal response ( J:98888 )

• during withdrawal from morphine the sniffing reflex is almost completely absent; however, the antinociceptive effect of morphine is similar to wild-type

impaired coordination ( J:98888 )

• poor performance in the rotating rod test but normal performance in the grip and string tests

• homozygotes had a normal startle response, associative learning ability, and working memory and did not show any depression or anxiety related symptoms

abnormal touch/ nociception ( J:98888 )

• the level at which homozygotes first detect a shock is normal; however, a greater shock intensity is needed to induce jumping

• pain sensitivity in the tail flick test was normal

growth/size/body

decreased body weight ( J:98888 )

nervous system

nervous system phenotype ( J:98888 )

N • no defects were detected in the development or morphology of the facial and trigeminal nuclei, the locus coeruleus, the sympathetic and parasympathetic ganglia, or cranial ganglia VII, IX, and X or in the gross morphology of the brain