Phenotypes Associated with This Genotype

Genotype
MGI:3581048

• Allelic Composition: Tg(Myh6-GFP,MAP2K3)58Ywa/?; Myl2^tm1(cre)Krc/Myl2⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:72242 )

• hemizygous or homozygous mice for Tg(Myh6-GFP,MAP2K3)58Ywa that are also heterozygous for Myl2^tm1(cre)Krc, in which cre mediated recombination is induced in cardiac muscle, display premature death between 5 and 7 weeks of age

respiratory system

pulmonary edema ( J:72242 )

• pulmonary edema

respiratory distress ( J:72242 )

• sign of dyspnea around time of death

homeostasis/metabolism

pulmonary edema ( J:72242 )

• pulmonary edema

cardiovascular system

abnormal myocardial fiber morphology ( J:72242 )

• heterogeneous myocyte atrophy

increased heart atrium size ( J:72242 )

• profoundly enlarged atria

increased heart weight ( J:72242 )

• increased atrial mass often filled with thrombosis

• external dimensions, and mass of ventricles are normal

thin ventricular wall ( J:72242 )

cardiac interstitial fibrosis ( J:72242 )

• trichrome staining shows substantial interstitial fibrotic tissues

abnormal cardiovascular system physiology ( J:72242 )

• systolic contractile depression and restrictive diastolic abnormalities

• increased end-systolic chamber volumes

muscle

abnormal myocardial fiber morphology ( J:72242 )

• heterogeneous myocyte atrophy

growth/size/body

increased heart weight ( J:72242 )

• increased atrial mass often filled with thrombosis

• external dimensions, and mass of ventricles are normal

cellular

cardiac interstitial fibrosis ( J:72242 )

• trichrome staining shows substantial interstitial fibrotic tissues