Phenotypes Associated with This Genotype

Genotype
MGI:3580671

• Allelic Composition: Ift88^fxo/Ift88^fxo
• Genetic Background: C3.B6J-Ift88^fxo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:86437 )

• development is arrested at E12.5-E13.5

nervous system

abnormal floor plate morphology ( J:86437 )

• lack of ventral midline groove in the neural plate

abnormal midbrain morphology ( J:86437 )

• sharp angle to mesencephalic flexure at E9.5-E10.5

limbs/digits/tail

polydactyly ( J:86437 )

• preaxial polydactyly

embryo

abnormal floor plate morphology ( J:86437 )

• lack of ventral midline groove in the neural plate