Phenotypes Associated with This Genotype

Genotype
MGI:3580480

• Allelic Composition: H2^dlAb1-Ea/H2^dlAb1-Ea
• Genetic Background: B6.129S2-H2^dlAb1-Ea/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:123934 )

• following infection with either a low or high dose of IOE, mice succumb to the infection at 11 to 15 days and 7 to 9 days, respectively, compared to wild-type mice, which succumb at 14 to 17 days and 8 to 12 days, respectively

immune system

increased susceptibility to bacterial infection ( J:123934 )

• mice are more susceptible to infection with a monocytotropic Ehrlichia bacteria from Ixodes ovatrus ticks (IOE) than wild-type mice

• following infection with either a low or high dose of IOE, mice succumb to the infection at 11 to 15 days and 7 to 9 days, respectively, compared to wild-type mice, which succumb at 14 to 17 days and 8 to 12 days, respectively

• mice have higher burdens of Ehrlichia bacteria in all organs following infection than do wild-type mice