About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3580446
Allelic
Composition		 Map2k3tm1Flv/Map2k3tm1Flv
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map2k3tm1Flv mutation (1 available); any Map2k3 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased T cell apoptosis ( J:85266 )
• CD4+T cells are resistant to activation-induced cell death and cytokine-withdrawal-induced apoptosis
abnormal CD4-positive, alpha-beta T cell physiology ( J:85266 )
• CD4+T cells are resistant to activation-induced cell death and cytokine-withdrawal-induced apoptosis

cellular
decreased T cell apoptosis ( J:85266 )
• CD4+T cells are resistant to activation-induced cell death and cytokine-withdrawal-induced apoptosis

hematopoietic system
decreased T cell apoptosis ( J:85266 )
• CD4+T cells are resistant to activation-induced cell death and cytokine-withdrawal-induced apoptosis
abnormal CD4-positive, alpha-beta T cell physiology ( J:85266 )
• CD4+T cells are resistant to activation-induced cell death and cytokine-withdrawal-induced apoptosis

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory