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Phenotypes Associated with This Genotype
Genotype
MGI:3580446
Allelic
Composition		 Map2k3tm1Flv/Map2k3tm1Flv
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map2k3tm1Flv mutation (1 available); any Map2k3 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased T cell apoptosis ( J:85266 )
• CD4+T cells are resistant to activation-induced cell death and cytokine-withdrawal-induced apoptosis
abnormal CD4-positive, alpha-beta T cell physiology ( J:85266 )
• CD4+T cells are resistant to activation-induced cell death and cytokine-withdrawal-induced apoptosis

cellular
decreased T cell apoptosis ( J:85266 )
• CD4+T cells are resistant to activation-induced cell death and cytokine-withdrawal-induced apoptosis

hematopoietic system
decreased T cell apoptosis ( J:85266 )
• CD4+T cells are resistant to activation-induced cell death and cytokine-withdrawal-induced apoptosis
abnormal CD4-positive, alpha-beta T cell physiology ( J:85266 )
• CD4+T cells are resistant to activation-induced cell death and cytokine-withdrawal-induced apoptosis

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory