Phenotypes Associated with This Genotype

Genotype
MGI:3580323

• Allelic Composition: Ccr2^tm1Ifc/Ccr2^tm1Ifc
• Genetic Background: B6.129S4-Ccr2^tm1Ifc/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to Coronaviridae infection induced morbidity/mortality ( J:106738 )

• mouse hepatitis virus (MHV-V5A13.1)-infected mice exhibit increased mortality compared with similarly treated wild-type mice

immune system

abnormal osteoclast differentiation ( J:149360 )

• osteoclastogenesis from bone marrow macrophages is less extensive than from wild-type cells

• osteoclasts derived from bone marrow macrophages are smaller with fewer nuclei than cells derived from wild-type bone marrow macrophages

• differentiation of preosteoclasts in ovariectomized mice is impaired compared to in wild-type mice

abnormal osteoclast cell number ( J:149360 )

• ovariectomized mice do not exhibit a change in osteoclast numbers unlike in similarly treated wild-type mice

decreased osteoclast cell number ( J:149360 )

• osteoclast number, covered bone surface, and size are decreased compared to in wild-type mice

abnormal leukocyte physiology ( J:122119 )

• in tumor models, myeloid suppressor cells exhibit 20- and 8-fold reduction migration into tumors and the spleen, respectively, compared with wild-type cells

• myeloid suppressor cells fail to promote growth of B16 melanoma cells when transplanted into wild-type mice unlike wild-type myeloid suppressor cells

abnormal leukocyte migration ( J:106738 )

• in mouse hepatitis virus (MHV-V5A13.1)-infected mice , T cells and microglia/macrophage infiltration of the central nervous system is decreased compared to in similarly treated wild-type mice

abnormal microglial cell physiology ( J:106738 )

• in mouse hepatitis virus (MHV-V5A13.1)-infected mice , microglia/macrophage infiltration of the central nervous system is decreased compared to in similarly treated wild-type mice

abnormal osteoclast physiology ( J:149360 )

• resorptive capacity of osteoclasts is decreased compared to wild-type cells

decreased interferon-gamma secretion ( J:106738 )

• 10-fold in the central nervous system of mouse hepatitis virus (MHV-V5A13.1)-infected mice

decreased acute inflammation ( J:106738 )

• Th1 response to MHV-V5A13.1 infection is decreased compared to in wild-type mice

increased susceptibility to Coronaviridae infection ( J:106738 )

• mouse hepatitis virus (MHV-V5A13.1)-infected mice exhibit increased mortality and viral recovery from the brain and decreased infiltration of T cells and microglia/macrophage in the central nervous system (CNS), IFN-gamma levels in the CNS, and demyelination compared with similarly treated wild-type mice

increased susceptibility to Coronaviridae infection induced morbidity/mortality ( J:106738 )

• mouse hepatitis virus (MHV-V5A13.1)-infected mice exhibit increased mortality compared with similarly treated wild-type mice

skeleton

abnormal osteoclast differentiation ( J:149360 )

• osteoclastogenesis from bone marrow macrophages is less extensive than from wild-type cells

• osteoclasts derived from bone marrow macrophages are smaller with fewer nuclei than cells derived from wild-type bone marrow macrophages

• differentiation of preosteoclasts in ovariectomized mice is impaired compared to in wild-type mice

abnormal osteoclast cell number ( J:149360 )

• ovariectomized mice do not exhibit a change in osteoclast numbers unlike in similarly treated wild-type mice

decreased osteoclast cell number ( J:149360 )

• osteoclast number, covered bone surface, and size are decreased compared to in wild-type mice

abnormal osteoclast physiology ( J:149360 )

• resorptive capacity of osteoclasts is decreased compared to wild-type cells

abnormal bone mineral density ( J:149360 )

• ovariectomized mice do not exhibit a change in bone marrow density unlike in similarly treated wild-type mice

abnormal trabecular bone morphology ( J:149360 )

increased trabecular bone volume ( J:149360 )

• mice exhibit a greater increase in trabecular bone volume fraction between 6 weeks and 10 weeks compared to in wild-type mice

abnormal bone trabecula morphology ( J:149360 )

• at 10 weeks, trabecular separation is decreased compared to in controls

increased trabecular bone thickness ( J:149360 )

decreased susceptibility to bone fracture ( J:149360 )

• mice exhibit an increase in force-to-failure values compared with wild-type mice

neoplasm

decreased tumor growth/size ( J:122119 )

• myeloid suppressor cells fail to promote growth of B16 melanoma cells when transplanted into wild-type mice unlike wild-type myeloid suppressor cells

nervous system

abnormal microglial cell physiology ( J:106738 )

• in mouse hepatitis virus (MHV-V5A13.1)-infected mice , microglia/macrophage infiltration of the central nervous system is decreased compared to in similarly treated wild-type mice

hematopoietic system

abnormal osteoclast differentiation ( J:149360 )

• osteoclastogenesis from bone marrow macrophages is less extensive than from wild-type cells

• osteoclasts derived from bone marrow macrophages are smaller with fewer nuclei than cells derived from wild-type bone marrow macrophages

• differentiation of preosteoclasts in ovariectomized mice is impaired compared to in wild-type mice

abnormal osteoclast cell number ( J:149360 )

• ovariectomized mice do not exhibit a change in osteoclast numbers unlike in similarly treated wild-type mice

decreased osteoclast cell number ( J:149360 )

• osteoclast number, covered bone surface, and size are decreased compared to in wild-type mice

abnormal leukocyte physiology ( J:122119 )

• in tumor models, myeloid suppressor cells exhibit 20- and 8-fold reduction migration into tumors and the spleen, respectively, compared with wild-type cells

• myeloid suppressor cells fail to promote growth of B16 melanoma cells when transplanted into wild-type mice unlike wild-type myeloid suppressor cells

abnormal leukocyte migration ( J:106738 )

• in mouse hepatitis virus (MHV-V5A13.1)-infected mice , T cells and microglia/macrophage infiltration of the central nervous system is decreased compared to in similarly treated wild-type mice

abnormal microglial cell physiology ( J:106738 )

• in mouse hepatitis virus (MHV-V5A13.1)-infected mice , microglia/macrophage infiltration of the central nervous system is decreased compared to in similarly treated wild-type mice

abnormal osteoclast physiology ( J:149360 )

• resorptive capacity of osteoclasts is decreased compared to wild-type cells

cellular

abnormal osteoclast differentiation ( J:149360 )

• osteoclastogenesis from bone marrow macrophages is less extensive than from wild-type cells

• osteoclasts derived from bone marrow macrophages are smaller with fewer nuclei than cells derived from wild-type bone marrow macrophages

• differentiation of preosteoclasts in ovariectomized mice is impaired compared to in wild-type mice

abnormal leukocyte migration ( J:106738 )

• in mouse hepatitis virus (MHV-V5A13.1)-infected mice , T cells and microglia/macrophage infiltration of the central nervous system is decreased compared to in similarly treated wild-type mice