About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3580323
Allelic
Composition
Ccr2tm1Ifc/Ccr2tm1Ifc
Genetic
Background
B6.129S4-Ccr2tm1Ifc/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr2tm1Ifc mutation (1 available); any Ccr2 mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mouse hepatitis virus (MHV-V5A13.1)-infected mice exhibit increased mortality compared with similarly treated wild-type mice

immune system
• osteoclastogenesis from bone marrow macrophages is less extensive than from wild-type cells
• osteoclasts derived from bone marrow macrophages are smaller with fewer nuclei than cells derived from wild-type bone marrow macrophages
• differentiation of preosteoclasts in ovariectomized mice is impaired compared to in wild-type mice
• ovariectomized mice do not exhibit a change in osteoclast numbers unlike in similarly treated wild-type mice
• osteoclast number, covered bone surface, and size are decreased compared to in wild-type mice
• in tumor models, myeloid suppressor cells exhibit 20- and 8-fold reduction migration into tumors and the spleen, respectively, compared with wild-type cells
• myeloid suppressor cells fail to promote growth of B16 melanoma cells when transplanted into wild-type mice unlike wild-type myeloid suppressor cells
• in mouse hepatitis virus (MHV-V5A13.1)-infected mice , T cells and microglia/macrophage infiltration of the central nervous system is decreased compared to in similarly treated wild-type mice
• in mouse hepatitis virus (MHV-V5A13.1)-infected mice , microglia/macrophage infiltration of the central nervous system is decreased compared to in similarly treated wild-type mice
• resorptive capacity of osteoclasts is decreased compared to wild-type cells
• 10-fold in the central nervous system of mouse hepatitis virus (MHV-V5A13.1)-infected mice
• Th1 response to MHV-V5A13.1 infection is decreased compared to in wild-type mice
• mouse hepatitis virus (MHV-V5A13.1)-infected mice exhibit increased mortality and viral recovery from the brain and decreased infiltration of T cells and microglia/macrophage in the central nervous system (CNS), IFN-gamma levels in the CNS, and demyelination compared with similarly treated wild-type mice
• mouse hepatitis virus (MHV-V5A13.1)-infected mice exhibit increased mortality compared with similarly treated wild-type mice

skeleton
• osteoclastogenesis from bone marrow macrophages is less extensive than from wild-type cells
• osteoclasts derived from bone marrow macrophages are smaller with fewer nuclei than cells derived from wild-type bone marrow macrophages
• differentiation of preosteoclasts in ovariectomized mice is impaired compared to in wild-type mice
• ovariectomized mice do not exhibit a change in osteoclast numbers unlike in similarly treated wild-type mice
• osteoclast number, covered bone surface, and size are decreased compared to in wild-type mice
• resorptive capacity of osteoclasts is decreased compared to wild-type cells
• ovariectomized mice do not exhibit a change in bone marrow density unlike in similarly treated wild-type mice
• mice exhibit a greater increase in trabecular bone volume fraction between 6 weeks and 10 weeks compared to in wild-type mice
• at 10 weeks, trabecular separation is decreased compared to in controls
• mice exhibit an increase in force-to-failure values compared with wild-type mice

neoplasm
• myeloid suppressor cells fail to promote growth of B16 melanoma cells when transplanted into wild-type mice unlike wild-type myeloid suppressor cells

nervous system
• in mouse hepatitis virus (MHV-V5A13.1)-infected mice , microglia/macrophage infiltration of the central nervous system is decreased compared to in similarly treated wild-type mice

hematopoietic system
• osteoclastogenesis from bone marrow macrophages is less extensive than from wild-type cells
• osteoclasts derived from bone marrow macrophages are smaller with fewer nuclei than cells derived from wild-type bone marrow macrophages
• differentiation of preosteoclasts in ovariectomized mice is impaired compared to in wild-type mice
• ovariectomized mice do not exhibit a change in osteoclast numbers unlike in similarly treated wild-type mice
• osteoclast number, covered bone surface, and size are decreased compared to in wild-type mice
• in tumor models, myeloid suppressor cells exhibit 20- and 8-fold reduction migration into tumors and the spleen, respectively, compared with wild-type cells
• myeloid suppressor cells fail to promote growth of B16 melanoma cells when transplanted into wild-type mice unlike wild-type myeloid suppressor cells
• in mouse hepatitis virus (MHV-V5A13.1)-infected mice , T cells and microglia/macrophage infiltration of the central nervous system is decreased compared to in similarly treated wild-type mice
• in mouse hepatitis virus (MHV-V5A13.1)-infected mice , microglia/macrophage infiltration of the central nervous system is decreased compared to in similarly treated wild-type mice
• resorptive capacity of osteoclasts is decreased compared to wild-type cells

cellular
• osteoclastogenesis from bone marrow macrophages is less extensive than from wild-type cells
• osteoclasts derived from bone marrow macrophages are smaller with fewer nuclei than cells derived from wild-type bone marrow macrophages
• differentiation of preosteoclasts in ovariectomized mice is impaired compared to in wild-type mice
• in mouse hepatitis virus (MHV-V5A13.1)-infected mice , T cells and microglia/macrophage infiltration of the central nervous system is decreased compared to in similarly treated wild-type mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/07/2021
MGI 6.17
The Jackson Laboratory