Phenotypes Associated with This Genotype

Genotype
MGI:3580267

• Allelic Composition: Akt3^tm1Hem/Akt3^tm1Hem
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

increased susceptibility to neuronal excitotoxicity ( J:98804 )

• hippocampal neuron cultures were more susceptible to glutamate and staurosporine induced cell death than in wildtype

decreased brain size ( J:98804 )

• first observed at 1 month of age and continued in adulthood, however homozygotes are viable, show no growth retardation and have normal glucose metabolism

• whole brain volume was reduced by about 24%

• reduced cell size and cell number in the adult brain

decreased brain weight ( J:98804 )

• about 25% reduction in adult brain weight, however at birth, brain weight did not differ from wildtype

abnormal brain ventricle morphology ( J:98804 )

• reduced volume of the ventricular spaces

decreased corpus callosum size ( J:98804 )

• reduced thickness of the corpus callosum

homeostasis/metabolism

increased susceptibility to neuronal excitotoxicity ( J:98804 )

• hippocampal neuron cultures were more susceptible to glutamate and staurosporine induced cell death than in wildtype

cellular

increased susceptibility to neuronal excitotoxicity ( J:98804 )

• hippocampal neuron cultures were more susceptible to glutamate and staurosporine induced cell death than in wildtype