Phenotypes Associated with This Genotype

Genotype
MGI:3580005

• Allelic Composition: Cdx2^tm1Fbe/Cdx2^tm1Fbe
• Genetic Background: involves: ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:98502 )

• homozygotes die around implantation

embryo

abnormal inner cell mass apoptosis ( J:98502 )

• a 3-fold increase in cell death is seen in the inner cell mass at E4.5

increased trophectoderm apoptosis ( J:98502 )

• an 8-fold increase in cell death is seen in the trophoectoderm at E4.5

failure of blastocyst to hatch from the zona pellucida ( J:98502 )

• at E4.5 embryos are still in the zona pellucida

abnormal blastocyst morphology ( J:98502 )

abnormal blastocoele morphology ( J:98502 )

• at E4.5, little or no blastocoelic cavity is seen

• the blastocoel is initially formed but collapses

abnormal trophectoderm morphology ( J:98502 )

• after 72 hours in culture (starting at the 8-cell stage) trophoectodermal cells appear rounded and non-epithelial

• tight and adherens junctions appear abnormal at the late blastocyst stage and it appears that the polarity and integrity of the trophoectoderm are not maintained

absent trophoblast giant cells ( J:98502 )

• trophoblast giant cells are not formed and trophoblast stem cell lines can not be established

abnormal trophoblast layer morphology ( J:98502 )

• trophoblast differentiation is impaired beyond the expanded blastocyst stage

cellular

abnormal inner cell mass apoptosis ( J:98502 )

• a 3-fold increase in cell death is seen in the inner cell mass at E4.5

increased trophectoderm apoptosis ( J:98502 )

• an 8-fold increase in cell death is seen in the trophoectoderm at E4.5