Phenotypes Associated with This Genotype

Genotype
MGI:3579853

• Allelic Composition: Mat1a^tm1Jmm/Mat1a^tm1Jmm
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Liver histology from 8 month old Mat1a^tm1Jmm/Mat1a^tm1Jmm mice fed a normal diet

growth/size/body

increased liver weight ( J:69408 )

• significantly increased at 3 months although the liver was histologically normal

homeostasis/metabolism

increased circulating methionine level ( J:69408 )

• plasma methionine levels elevated 776%

liver/biliary system

abnormal liver morphology ( J:69408 )

increased liver weight ( J:69408 )

• significantly increased at 3 months although the liver was histologically normal

macrovesicular hepatic steatosis ( J:69408 )

• choline deficient diet causes severe macrovesicular steatosis in the liver

• severe macrovesicular steatosis in the liver in 8 month old mice on a normal diet

abnormal liver physiology ( J:69408 )

• levels of methionine metabolites were reduced in the liver

liver inflammation ( J:69408 )

• focal areas of inflammation are seen involving the liver cells that contain fat (steatohepatitis); inflammatory component is chiefly lymphocytic

immune system

liver inflammation ( J:69408 )

• focal areas of inflammation are seen involving the liver cells that contain fat (steatohepatitis); inflammatory component is chiefly lymphocytic