Phenotypes Associated with This Genotype

Genotype
MGI:3579852

• Allelic Composition: Tbx20^tm1.1Sev/Tbx20^tm1.1Sev
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:98516 )

• death at E10.5

cardiovascular system

failure of heart looping ( J:98516 )

• looping is blocked

abnormal heart tube morphology ( J:98516 )

• at E9.5 the heart is unlooped, hourglass shaped, and severely hypoplastic

heart hypoplasia ( J:98516 )

abnormal fetal cardiomyocyte proliferation ( J:98516 )

• decreased proliferation is seen atE8.0 and E8.5; however, apoptosis is not increased

embryo

embryonic growth arrest ( J:98516 )

• growth arrest at E9.0

muscle

abnormal fetal cardiomyocyte proliferation ( J:98516 )

• decreased proliferation is seen atE8.0 and E8.5; however, apoptosis is not increased

cellular

abnormal fetal cardiomyocyte proliferation ( J:98516 )

• decreased proliferation is seen atE8.0 and E8.5; however, apoptosis is not increased