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Phenotypes Associated with This Genotype
Genotype
MGI:3579845
Allelic
Composition
Tbx20tm1.1Rph/Tbx20+
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx20tm1.1Rph mutation (1 available); any Tbx20 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• left atrial dilation is seen
• the left ventricle diastolic dimension is mildly but significantly increased
• left ventricular wall thickness was decreased by 35%
• signs of dilated cardiomyopathy are seen but no compensatory myocardial hypertrophy or change in heart weight are detected
• left ventricular systolic dimension was increased 42% and fractional shortening was decreased by 21%

muscle
• signs of dilated cardiomyopathy are seen but no compensatory myocardial hypertrophy or change in heart weight are detected
• left ventricular systolic dimension was increased 42% and fractional shortening was decreased by 21%

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
dilated cardiomyopathy DOID:12930 OMIM:PS115200
J:98489


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory