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Phenotypes Associated with This Genotype
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd2aptm1Shaw mutation (1 available); any Cd2ap mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• ferritin injection did not induce the formation of multivesicular bodies as it did in wildtype
• exhibited glomerular lesions of varying degrees at 9 months of age but not at 6 months of age and this pathology at 9 months of age was similar to that seen in 3-4 week old homozygous null mice
• observed infiltration of inflammatory leukocytes in some glomeruli
• observed electon-dense mesangial deposits that occluded the capillary lumen, subepithelial and subendothelial deposits along the glomerular basement membrane, and in some older mice, highly organized microtubular deposits in the mesangium
• exhibited increased mesangial cellularity at 9 months of age but not at 6 months of age
• exhibited expansion of the mesangial matrix at 9 months of age but not at 6 months of age
• observed immunoglobulin deposits in either punctate or linear patterns at the glomerular basement membrane in 4 out of 20 heterozygotes, however did not develop proteinuria

• increased susceptibility to glomerular injury when injected with a low dose of nephrotoxic antibody, with heterozygotes developing more severe and persistent proteinuria and even resulting in death of some mutants compared to wildtype

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.12
The Jackson Laboratory