Phenotypes Associated with This Genotype

Genotype
MGI:3579581

• Allelic Composition: Gjd2^tm1Kwi/Gjd2^tm1Kwi
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal retina ganglion layer morphology ( J:98181 )

• coupling pattern of alpha-ganglion cells to amacrine cells and other alpha-ganglion cells is absent, however homozygotes develop normally and showed no loss of ganglion cells

nervous system

abnormal nervous system electrophysiology ( J:99856 )

• correlated spiking is absent in mitral cell pairs from the same olfactory glomerulus

• mitral pairs are not electrically coupled; input resistance of mitral cells is higher than in wild-type cells

digestive/alimentary system

digestive/alimentary phenotype ( J:117402 )

N • pancreatic islets develop apparently normally in mutants

endocrine/exocrine glands

decreased insulin secretion ( J:117402 )

• insulin secretion is prevented at physiological concentrations of glucose (<8 mM), and is reduced at higher sugar levels (>16.7 mM)

homeostasis/metabolism

decreased insulin secretion ( J:117402 )

• insulin secretion is prevented at physiological concentrations of glucose (<8 mM), and is reduced at higher sugar levels (>16.7 mM)