Phenotypes Associated with This Genotype

Genotype
MGI:3579531

• Allelic Composition: Mdk^tm1Tmu/Mdk^tm1Tmu
• Genetic Background: 129S2-Mdk^tm1Tmu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal learning/memory/conditioning ( J:76278 )

• impaired short-term memory using a Y-shaped maze test at 4 weeks but not at 8 weeks

increased anxiety-related response ( J:76278 )

• seen in 4 week old animals but not in 8 week old animals

• less time in the open on an elevated-plus maze

• increased defecation in an open field test

nervous system

abnormal hippocampus development ( J:60666 )

• delayed development of the hippocampus

abnormal dentate gyrus morphology ( J:76278 )

• retarded development

cardiovascular system

abnormal vascular endothelial cell morphology ( J:60666 )

• suppressed on day 14 after carotid ligation

• few inflammatory leukocytes at points of intimal lesions

• lumen circumference significantly increased but not the external elastic lamina

renal/urinary system

tubular nephritis ( J:93637 )

• neutrophil infiltration of the tubulointerstitium slower to develop and faded more rapidly than in control mice

kidney failure ( J:93637 )

• less mortality from kidney failure after cisplatin administration- 90% survival to 7 days as opposed to 30% for controls

• fewer apoptotic cells

• indicators of kidney damage such as BUN, casts, tubular dilation and degeneration all higher than in controls

immune system

tubular nephritis ( J:93637 )

• neutrophil infiltration of the tubulointerstitium slower to develop and faded more rapidly than in control mice