Phenotypes Associated with This Genotype

Genotype
MGI:3579482

• Allelic Composition: Plxna3^tm1Matl/Y; Plxna4^tm1Matl/Plxna4^tm1Matl
• Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6) or (involves: 129P2/OlaHsd * 129S1/Sv * CD-1)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal axon guidance ( J:98440 )

♂ • repulsive effect of Sema3A on axon growth from sensory neurons of the dorsal root ganglia and of superior cervical ganglion neurons was eliminated

abnormal sensory neuron innervation pattern ( J:98440 )

♂ • starting at E11.5, had severely disrupted peripheral sensory projections, with many axons crossing the dorsal midline to the other side of the body at E12.5

♂ • peripheral sensory projections exhibited extensive outgrowth and branching as if there were no boundaries for the axons

abnormal trigeminal nerve morphology ( J:98440 )

♂ • severely disorganized and derasciculated ophthalmic, maxillary and mandibular projections at E11.5

♂ • more fibers of the ophthalmic branch misprojected in different directions, and some even started to invade the eye region at E11.5 and the ophthalmic axon fibers covered the entire face, including the eyes and the fibers were thinner and heavily branched at E12.5 compared to wildtype

abnormal trochlear nerve morphology ( J:98440 )

♂ • severely defasciculated even though individual axons could still be seen leaving the midbrain-hindbrain junction

cellular

abnormal axon guidance ( J:98440 )

♂ • repulsive effect of Sema3A on axon growth from sensory neurons of the dorsal root ganglia and of superior cervical ganglion neurons was eliminated