Phenotypes Associated with This Genotype

Genotype
MGI:3579467

• Allelic Composition: Ngef^tm1Meg/Ngef^tm1Meg
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal axon extension ( J:98309 )

• axons from cultured retinal ganglion cells were significantly shorter

• the number of neurites per cell was unaltered

• upon exposure to ephrin-A1 significantly fewer retinal ganglion cell growth cones collapse

• however, by axon tracing experiments, no defect in axon pathfinding in retinogeniculate, retinocollicular, or corticospinal tracts are found in vivo

cellular

abnormal axon extension ( J:98309 )

• axons from cultured retinal ganglion cells were significantly shorter

• the number of neurites per cell was unaltered

• upon exposure to ephrin-A1 significantly fewer retinal ganglion cell growth cones collapse

• however, by axon tracing experiments, no defect in axon pathfinding in retinogeniculate, retinocollicular, or corticospinal tracts are found in vivo