Mouse Genome Informatics
hm
    Mc4rtm1Dhu/Mc4rtm1Dhu
involves: 129S4/SvJae * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
growth/size/body
• slower metabolic response to higher fat in the diet as measured by VO2
• increased body length at 19 weeks, disregarding tails
• weight normal until after 4 weeks of age (J:38224)
• by 5 weeks most mice were heavier than controls (J:38224)
• after 7 weeks, all mice were heavier than controls, by 50% for males and 2 fold for females (J:38224)
• conventionally housed mice are heavier than controls and heavier than mice with free access to a running wheel (J:94617)
• rapidly gain weight when no longer able to exercise but weight gain is reversed somewhat if opportunity to exercise is restored (J:94617)

behavior/neurological
• more active in daylight
• the stress of isolation inhibits feeding
• hyperphagia (J:38224)
• food consumption in females increased by 46% (J:38224)
• food consumption normal when given free access to a running wheel but become hyperphagic when access to running wheels is removed (J:94617)
• tended to exercise somewhat less than controls when given access to a running wheel

homeostasis/metabolism
• slower metabolic response to higher fat in the diet as measured by VO2
• levels elevated 1.5X in males and 4.5X in females at 4-8 weeks of age
• levels elevated 2.5X in males and 6.5X in females at 17-23 weeks of age
• in males only by 10-14 weeks of age
• at 17-23 weeks of age male blood glucose levels are 2X normal
• hyperinsulinemia in both males and females
• levels increased 5 fold in males and 9 fold in females at 4-8 weeks of age
• at 17-23 weeks of age levels increased to 14X normal in males and to 60X normal in females

reproductive system
• conventionally housed animals reproduced poorly, far fewer litters
• reproduced almost as well as controls when able to exercise

skeleton
• reduced number of osteoclasts
• exhibit high bone mass at 6 months of age

hematopoietic system
• reduced number of osteoclasts

immune system
• reduced number of osteoclasts

Mouse Models of Human Disease
OMIM IDRef(s)
Obesity 601665 J:38224