Phenotypes Associated with This Genotype

Genotype
MGI:3579020

• Allelic Composition: Adrb2^tm1Bkk/Adrb2^tm1Bkk
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal osteoblast physiology ( J:97566 )

• isoproterenol did not enhance the generation of osteoclasts when homozygous mutant osteoblasts were co-cultured with wildtype bone marrow macrophages, like it did in wildtype

abnormal osteoclast morphology ( J:97566 )

• decreased osteoclast surface in homozygous mutant bones

abnormal osteoclast differentiation ( J:97566 )

• decreased number of tartrate-resistant acid phosphatase (TRAP)-positive multi-nucleated osteoclasts, indicating defective osteoclast differentiation

abnormal osteoclast physiology ( J:97566 )

• bone resorption did not increase in gonadectomized homozygous mutant mice

• decrease in urinary elimination of deoxypyridinoline, a marker of osteoclast function

increased bone mass ( J:97566 )

• increased bone volume/tissue volume and bone formation rate, showing a severe high bone mass phenotype at 6 months of age

• long-term leptin intracerebroventricular infusion or gonadectomy did not reduce bone mass of homozygous mutant mice

abnormal bone resorption ( J:97566 )

• increased bone formation rate and decreased bone resorption

decreased bone resorption ( J:97566 )

hematopoietic system

abnormal osteoclast morphology ( J:97566 )

• decreased osteoclast surface in homozygous mutant bones

abnormal osteoclast differentiation ( J:97566 )

• decreased number of tartrate-resistant acid phosphatase (TRAP)-positive multi-nucleated osteoclasts, indicating defective osteoclast differentiation

abnormal osteoclast physiology ( J:97566 )

• bone resorption did not increase in gonadectomized homozygous mutant mice

• decrease in urinary elimination of deoxypyridinoline, a marker of osteoclast function

immune system

abnormal osteoclast morphology ( J:97566 )

• decreased osteoclast surface in homozygous mutant bones

abnormal osteoclast differentiation ( J:97566 )

• decreased number of tartrate-resistant acid phosphatase (TRAP)-positive multi-nucleated osteoclasts, indicating defective osteoclast differentiation

abnormal osteoclast physiology ( J:97566 )

• bone resorption did not increase in gonadectomized homozygous mutant mice

• decrease in urinary elimination of deoxypyridinoline, a marker of osteoclast function

cellular

abnormal osteoclast differentiation ( J:97566 )

• decreased number of tartrate-resistant acid phosphatase (TRAP)-positive multi-nucleated osteoclasts, indicating defective osteoclast differentiation

abnormal osteoblast physiology ( J:97566 )

• isoproterenol did not enhance the generation of osteoclasts when homozygous mutant osteoblasts were co-cultured with wildtype bone marrow macrophages, like it did in wildtype