Phenotypes Associated with This Genotype

Genotype
MGI:3578769

• Allelic Composition: Mfn1^tm1Dcc/Mfn1^tm1Dcc
• Genetic Background: involves: 129S/SvEv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:81438 )

• frequency of homozygous embryos normal up to E10.5

• 20% of homozygotes resorbed at E11.5

• 86% of homozygotes resorbed at E12.5

embryo

embryonic growth retardation ( J:81438 )

• observed at E8.5

• often deformed as well

decreased embryo size ( J:81438 )

• embryos significantly smaller than controls at E8.5

cellular

abnormal mitochondrial morphology ( J:81438 )

• fragmented mitochondria

abnormal mitochondrial physiology ( J:81438 )

• mitochondrial fusion reduced

• mobility severely affected

• individual mitochondria functionally defective

growth/size/body

embryonic growth retardation ( J:81438 )

• observed at E8.5

• often deformed as well

decreased embryo size ( J:81438 )

• embryos significantly smaller than controls at E8.5