Phenotypes Associated with This Genotype

Genotype
MGI:3578660

• Allelic Composition: Slc11a2^tm2Nca/Slc11a2^tm2Nca; Tg(Vil1-cre)20Syr/?
• Genetic Background: involves: 129S6.129S4-Slc11a2^tm2Nca * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

extramedullary hematopoiesis ( J:98088 )

• sinusoid areas of the liver particularly

• dysplastic erythropoiesis in the spleen

anemia ( J:98088 )

• progressive anemia developed after birth

• profound but not as severe as in knock-out mice

abnormal erythrocyte morphology ( J:98088 )

abnormal spleen morphology ( J:98088 )

enlarged spleen ( J:98088 )

decreased spleen iron level ( J:98088 )

• decreased non-heme iron in the spleen

increased spleen red pulp amount ( J:98088 )

• expanded red pulp

homeostasis/metabolism

decreased heart iron level ( J:98088 )

• decreased non-heme iron in the heart

decreased spleen iron level ( J:98088 )

• decreased non-heme iron in the spleen

decreased brain iron level ( J:98088 )

• diminished non-heme iron levels in the brain

decreased kidney iron level ( J:98088 )

• decreased non-heme iron

decreased liver iron level ( J:98088 )

• decreased non-heme iron in the liver

cardiovascular system

decreased heart iron level ( J:98088 )

• decreased non-heme iron in the heart

enlarged heart ( J:98088 )

immune system

abnormal spleen morphology ( J:98088 )

enlarged spleen ( J:98088 )

decreased spleen iron level ( J:98088 )

• decreased non-heme iron in the spleen

increased spleen red pulp amount ( J:98088 )

• expanded red pulp

liver/biliary system

decreased liver iron level ( J:98088 )

• decreased non-heme iron in the liver

renal/urinary system

decreased kidney iron level ( J:98088 )

• decreased non-heme iron

nervous system

decreased brain iron level ( J:98088 )

• diminished non-heme iron levels in the brain

growth/size/body

enlarged heart ( J:98088 )

enlarged spleen ( J:98088 )