Phenotypes Associated with This Genotype

Genotype
MGI:3578659

• Allelic Composition: Hfe^tm2Nca/Hfe^tm2Nca; Slc11a2^tm1Nca/Slc11a2^tm1Nca
• Genetic Background: involves: 129S6/SvEvTac * 129S6.129S4-Slc11a2^tm1Nca

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:98088 )

N • considerably improved survival

homeostasis/metabolism

increased liver iron level ( J:98088 )

• liver non-heme iron levels higher than in Slc11a2 knock-out mice at 12 weeks of age

hematopoietic system

decreased hematocrit ( J:98088 )

• but improved over condition seen in inSlc11a2 knockout mice

growth/size/body

postnatal growth retardation ( J:98088 )

• body weight considerably better than inSlc11a2 knockout mice at 12 weeks of age

liver/biliary system

increased liver iron level ( J:98088 )

• liver non-heme iron levels higher than in Slc11a2 knock-out mice at 12 weeks of age