Phenotypes Associated with This Genotype

Genotype
MGI:3578558

• Allelic Composition: Plcg2^Ali5/Plcg2⁺; Rag1^tm1Mom/Rag1^tm1Mom
• Genetic Background: involves: 129S7/SvEvBrd * C3HeB/FeJ * C3HeB/FeJ-Plcg2^Ali5

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

chronic inflammation ( J:97930 )

• approximately 70% of homozygous mice developed despite absence of B and T cells

osteoarthritis ( J:97930 )

• resulting in severe arthritis of the small joints of the paws and missing phalanges

dermatitis ( J:97930 )

• in the superficial layers of the skin of the paws and ears

skeleton

osteoarthritis ( J:97930 )

• resulting in severe arthritis of the small joints of the paws and missing phalanges

integument

dermatitis ( J:97930 )

• in the superficial layers of the skin of the paws and ears