Phenotypes Associated with This Genotype

Genotype
MGI:3578361

• Allelic Composition: Nr5a2^tm1Lex/Nr5a2^tm1Lex
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:97625 )

• fewer than expected homozygous embryos are found at E6.5 - E7.0 and no homozygous embryos are found at E7.5 - E9.5

embryonic lethality between implantation and somite formation, incomplete penetrance ( J:97625 )

• fewer than expected homozygous embryos are found at E6.5 - E7.0

embryo

abnormal embryo development ( J:97625 )

• at E6.5 - E7.0, the extraembryonic and embryonic tissues are not readily distinguished from each other

abnormal ectoderm development ( J:97625 )

• the ectoderm is disorganized

decreased embryo size ( J:97625 )

• at E6.5 - E7.0

abnormal proamniotic cavity morphology ( J:97625 )

• the proamniotic cavity is malformed

abnormal visceral endoderm morphology ( J:97625 )

• the visceral endoderm is expanded and the cells are loosely arranged

growth/size/body

decreased embryo size ( J:97625 )

• at E6.5 - E7.0