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Phenotypes Associated with This Genotype
Genotype
MGI:3578359
Allelic
Composition		 Rdh11tm1Tsyk/Rdh11tm1Tsyk
Rdh5tm1Drie/Rdh5tm1Drie
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rdh11tm1Tsyk mutation (0 available); any Rdh11 mutation (17 available)
Rdh5tm1Drie mutation (0 available); any Rdh5 mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal eye electrophysiology ( J:97788 )
• slightly reduced a- and b-wave amplitude responses are seen under dark adapted conditions
delayed dark adaptation ( J:97788 )
• delayed dark adaptation and decreased 11-cis-retinal levels following exposure to intense bleaching conditions (500 cd/m2 for 3 minutes)
• more severely delayed than in either single homozygote

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory