Mouse Genome Informatics
hm
    Mmetm1Cge/Mmetm1Cge
involves: 129S4/SvJae * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
liver/biliary system
• diffuse hemorrhagic necrosis at death after treatment with combined endotoxin lipopolysaccharide and D-galactosamine or the combination of TNFalpha and Il1b

homeostasis/metabolism
• mice have elevated plasma levels of amyloid beta 42 and 40 relative to controls
• amyloid beta40 and 42 protein levels are elevated in mutant vs controls at 3-6 and at 11 months of age

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:69830