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Phenotypes Associated with This Genotype
Genotype
MGI:3577843
Allelic
Composition
Mmetm1Cge/Mmetm1Cge
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmetm1Cge mutation (0 available); any Mme mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
liver/biliary system
• diffuse hemorrhagic necrosis at death after treatment with combined endotoxin lipopolysaccharide and D-galactosamine or the combination of TNFalpha and Il1b (J:70516)
• diffuse hemorrhagic necrosis at death after treatment with combined endotoxin lipopolysaccharide and D-galactosamine or the combination of TNFalpha and Il1b (J:70516)

homeostasis/metabolism
• mice have elevated plasma levels of amyloid beta 42 and 40 relative to controls (J:104962)
• mice have elevated plasma levels of amyloid beta 42 and 40 relative to controls (J:104962)
• amyloid beta40 and 42 protein levels are elevated in mutant vs controls at 3-6 and at 11 months of age (J:104962)
• amyloid beta40 and 42 protein levels are elevated in mutant vs controls at 3-6 and at 11 months of age (J:104962)

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:69830


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory