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Phenotypes Associated with This Genotype
Genotype
MGI:3577612
Allelic
Composition		 Irf3tm1Ttg/Irf3tm1Ttg
Irf9tm1Ttg/Irf9tm1Ttg
Genetic
Background		 involves: 129S/SvEv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf3tm1Ttg mutation (3 available); any Irf3 mutation (35 available)
Irf9tm1Ttg mutation (2 available); any Irf9 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal cytokine secretion ( J:98127 )
• Newcastle disease virus infected MEFs had undetectable interferon-alpha/beta activity, indicating that mutant MEFs are incapable of responding to infection

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory