Phenotypes Associated with This Genotype

Genotype
MGI:3577402

• Allelic Composition: Tg(Myh6-Ppif)26.2Jmol/0
• Genetic Background: FVB/N-Tg(Myh6-Ppif)26.2Jmol

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal myocardial fiber mitochondrial morphology ( J:97660 )

• this transgene only affects mitochondria in the heart

• mitochondrial architecture but not numbers was affected

cellular

abnormal myocardial fiber mitochondrial morphology ( J:97660 )

• this transgene only affects mitochondria in the heart

• mitochondrial architecture but not numbers was affected

abnormal mitochondrial crista morphology ( J:97660 )

• loss of cristae was seen at 2 months of age

dilated mitochondrion ( J:97660 )

• mitochondrial swelling was seen at 2 months of age

increased apoptosis ( J:97660 )

• in the heart

muscle

abnormal myocardial fiber mitochondrial morphology ( J:97660 )

• this transgene only affects mitochondria in the heart

• mitochondrial architecture but not numbers was affected